Abstract The performance of healthy volunteer subjects on an auditory
latent inhibition (LI) paradigm was *****sed following administration of
a single oral dose ofd-amphetamine or placebo. It was predicted that a
low (5 mg), but not a high (10 mg), dose ofd-amphetamine would disrupt
LI. The prediction was sup****ted with left ear presentation of the
preexposed stimulus only. When the preexposed stimulus was presented to
the right ear the predicted pattern of findings was not obtained. It is
concluded that the dopaminergic system is involved in the mediation of
LI in man and it is speculated that the interaction between amphetamine
dose and ear of presentation of the preexposed stimulus may reflect
normally occurring dopaminergic hemisphere asymmetry.
http://www.springerlink.com/content/7j12w57611317777/
