Abstract Friedreich Ataxia (FRDA), the most frequent inherited ataxia,
is not only characterized by progressive gait and limb ataxia, but in
most cases is also accompanied by a severe hypertrophic cardiomyopathy.
This life threatening symptom can be ameliorated by the administration
of idebenone, a short chain quinone antioxidant, sup****ting additional
evidence that oxidative stress plays a major role in the pathogenesis of
this disease. In this study we analyze the combinatorial effect of
different antioxidants on cell viability of FRDA fibroblasts and of
RAT-1 immortalized fibroblasts exposed to oxidative stress. We find that
an equimolar mixture of idebenone and vitamin E is more potent than each
of the compound alone. Increased potency was also obtained with a novel
synthetic antioxidant (Fe-Aox29) combining the active groups from both
idebenone and vitamin E. These results indicate, that idebenone and
vitamin E might act synergistically to counteract oxidative stress in
fibroblasts from FRDA patients.
http://www.springerlink.com/content/281w0603445804j1/
>Fe-Aox29 Sounds crazy awesome
