HaltingState <HaltingState@[EMAIL PROTECTED]
> wrote in
news:gf5u00$p9t$1@[EMAIL PROTECTED]
> SDer wrote:
>> HaltingState <HaltingState@[EMAIL PROTECTED]
> wrote in
>> news:gf32qj$nre$1@[EMAIL PROTECTED]
>>
>>> SDer wrote:
>>>> HaltingState <HaltingState@[EMAIL PROTECTED]
> wrote in
>>>> news:gf0t41$l28$1@[EMAIL PROTECTED]
>>>>
>>>>> Post any studies on creatine that you may have come across.
>>>>>
>>>>>
>>>>> While the role of creatine in preventing muscle (peripheral)
>>>>> fatigue for high performance athletes is well understood, its
>>>>> biochemical role in prevention of mental (central) fatigue is not.
>>>>> Creatine is abundant in muscles and the brain and after
>>>>> phosphorylation used as an energy source for adenosine
>>>>> triphosphate synthesis. Using double-blind placebo-controlled
>>>>> paradigm, we demonstrated that dietary supplement of creatine (8
>>>>> g/day for 5 days) reduces mental fatigue when subjects repeatedly
>>>>> perform a simple mathematical calculation. After taking the
>>>>> creatine supplement, task-evoked increase of cerebral oxygenated
>>>>> hemoglobin in the brains of subjects measured by near infrared
>>>>> spectroscopy was significantly reduced, which is compatible with
>>>>> increased oxygen utilization in the brain.
>>>>>
>>>>> http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0H-454T
>>>>> R7 3-
>>>>> 2&_user=681891&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000
>>>>> 03 74
>>>>> 19&_version=1&_urlVersion=0&_userid=681891&md5=8cb5a175782e7cdd9dad
>>>>> b3 b7 c8d165db
>>>>>
>>>> I have found that creatine can help with mental fatigue, but the
>>>> problem I faced was that it was hard on the stomach, no matter what
>>>> brand I tried. Its EEC form was also great.
>>> EEC form? What is EEC?
>>
>> Ethyl-Ester-Creatine, which is better in pill form as it tastes like
>> battery acid.
>>
>>> It is much easier to take down if you use green tea to dissolve it.
>>> I found that for whatever reason that it dissolves more effectively
>>> and gives less stomach irritation. Some drinks do not seem to
>>> dissolve it at all.
>>
>> I hadn't thought of that.
>>
>>> I am currently looking at arginine, glycine, and methionine
>>> supplementation as a means of increasing creatine concentration
>>> beyond what would normally be possible via dietary intake of
>>> creatine alone.
>>>
>>> Glycine also seems to have other interesting nootropic effects, but
>>> I have no tried it yet personally.
>>>
>>
>> I would be sceptical about arginine and methionine. Arginine can mess
>> up your blood pressure, which might be a good or even pleasant thing
>> sometimes, depending on your situation. Methionine can make you
>> really sick if your methylic cycle is already messed (again depending
>> on your individual situation, but a word of caution is never a bad
>> idea).
>
> Do you have any information on Methionine inducing disease? That is
> interesting and I have not heard about that before.
>
> I was told that chronic arginine administration upregulates enzymes
> that metabolize NO and possible down regulates enzymes that convery
> argininte into NO. Thereby reducing the basal level of NO and hence
> reducing vaso-dilation and blood flow when arginine is not being used.
> I however have not read anything specific on this. Any information
> or experience that you could share would be appreciated.
>
Here is a page on the subject of methylation:
http://www.enzymestuff.com/methylation.htm
The methylation cycle can be quite complicated, and IMO the bottom line
is that experimenting with it can prove beneficial, but not always.
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