Post any studies on creatine that you may have come across.
While the role of creatine in preventing muscle (peripheral) fatigue for
high performance athletes is well understood, its biochemical role in
prevention of mental (central) fatigue is not. Creatine is abundant in
muscles and the brain and after phosphorylation used as an energy source
for adenosine triphosphate synthesis. Using double-blind
placebo-controlled paradigm, we demonstrated that dietary supplement of
creatine (8 g/day for 5 days) reduces mental fatigue when subjects
repeatedly perform a simple mathematical calculation. After taking the
creatine supplement, task-evoked increase of cerebral oxygenated
hemoglobin in the brains of subjects measured by near infrared
spectroscopy was significantly reduced, which is compatible with
increased oxygen utilization in the brain.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0H-454TR73-2&_user=681891&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000037419&_version=1&_urlVersion=0&_userid=681891&md5=8cb5a175782e7cdd9dadb3b7c8d165db
