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Drugs Network > Opium > Re: No toleranc...
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Re: No tolerance... painkillers don't get me high?!

by "Dilaudid" <dilaudid@[EMAIL PROTECTED] > Jan 14, 2008 at 09:46 PM

"Low levels of s*****onin may be associated with several disorders, namely
increase in aggressive and angry behaviors, clinical depression,
obsessive-compulsive disorder (OCD), migraine, irritable bowel syndrome,
tinnitus, fibromyalgia, bipolar disorder and anxiety disorders.[citation
needed] If neurons of the brainstem that make s*****onin - s*****onergic
neurons - are abnormal in infants, there is a risk of sudden infant death
syndrome (SIDS).[5][6] Low levels of s*****onin may also be associated with
intense religious experiences.[7]
Recent research conducted at Rockefeller University shows that in both
patients who suffer from depression and in mice that model that disease,
levels of the p11 protein are decreased. This protein is related to
s*****onin transmission within the brain.[8]
http://en.wikipedia.org/wiki/S*****onin"
As you can see above a s*****onin deficiency is not a contributing factor
to
ADD or ADHD rather it is more likely associated with bi-polar disorder. I
went through two years of therapy for this before it was determined I had
ADD, ADHD instead. Looking below you will discover psychedelics and
amphetamine [MDMA] type drugts tend to affect this chemical receptor.
Additionally, a whole class of antidepressants target the s*****onin
reuptake
in the nerve synapse SSRI's [watch out for these they will positively ****
up ***ual function leaving the greater majority of patients under
psychiatric care choosing to discontinue care to continue functioning
***ually. Dopamine is also intrinsically linked to ***ual function however
it dramatically prolongs ***ual function when stimulated with opiates
making
the usual five minute ordeal a forty-five minute episode [so if you
promise
her she'll be leaving wit rugburns on er ass yo ain't kiddin!

I am uncertain to what extent your relation****p with opiates is however I
can promise you it is a complete waste of time to extract hydrocodone from
the pills you get. The yield is just too low with too much going to waste
to
be of any real value. Check into this on your own if you like but hard
core
hydrocodone addicts easily pop 25-30 of them things a day without the
known
liver effects associated with acetaminophen. The better alternative is to
seek stronger meds like Percocet/Percodan or better yet opium tea which
takes all the alkaloids in the poppy into consideration. This is a long
acting alternative to some rather short duration drugs. The problem with
pharmaceuticals is their orientation towards a particular effect mostly,
they hit hard and taper off fast leaving the user sampling them several
times daily. This does lead to a generally run down feeling with the
additional side effects of the acetaminophen tearing up the liver. Cold
water extraction is just a polite way of delaying the inevitable
graduation
to a stronger opiate. This extraction method is very unfortunate in your
case because you will build tolerance lightening fast. Realize tolerance
is
as simple as taking five pills one day and four the next. The following
day
will be a disappointment. Careful regulation of these meds is necessary to
maximize the experience. DO NOT TAKE ONE MORE PILL THAN ABSOLUTELY
NECESSARY
TO GET YOU WHERE YOU WANT TO BE! Use Adjuncts and synergistic compounds to
lengthen and maximize the effects or you will find yourself addicted and
what is worse, you won't get high from the addiction. his is a very real
prospect of messing with these meds.

Lots of things could have been different as to why you are failing to
experience the effects you want from the meds. Eating some sort of food
that
has natural antagonist properties to an adverse interaction with vitamins.
You will need to examine everything that you experience to determine whats
up. Also be prepared for the possibility you have ruined your op****tunity
to
benefit from the hydrocodone. Taking it rectally could have totally ****ed
your ability to feel buzzed due to tolerance. Think of the drugs like
poison, once your body builds up antigens negating the effects of the
poison, it becomes very unlikely that you will ever be jeopardized by the
toxin again. That is how s**** charmers in India receive several Cobra
bites
without dying.

You are likely stuck with two choices with hydrocodone; 1. large
quantities
to get loaded or 2. always taking it rectally [subjecting yourself to
considerable risk due to respiratory depression]. In either case you will
either give up on the med or graduate to a stronger opioid. Additionally,
you may find the s*****oninergic agonists identified below far more
suitable
to your tastes. Good Luck


S*****onergic drugs
Several cl***** of drugs target the 5-HT system including some
antidepressants, antipsychotics, anxiolytics, antiemetics, and
antimigraine
drugs as well as the psycoactive drugpsychoactive psychedelic drugs and
empathogens.
Psychoactive drugs
The psychedelic drugs psilocin/psilocybin, DMT, mescaline, and LSD mimick
the action of s*****onin at 5-HT2A receptors. The empathogen MDMA (ecstasy)
releases s*****onin from synaptic vesicles of neurons.


<ki0687@[EMAIL PROTECTED]
> wrote in message
news:ead1e5f2-c265-4188-b433-6b525752b8e8@[EMAIL PROTECTED]
> Dilaudid, your post did intrigue me. I also suffer from a seretonin
> deficiency (I think I have around half of what I should have.. meh...)
> and have adhd and depression because of it. I say I can't get high
> because once a few months ago I took 60mg hydro and did actually get
> high, and know what the effects are. I don't know what was different,
> but I'm sure it wasnt my extraction method (I only used cold water
> extract on 25mg, and even then I'm 90% sure i did it right). Could I
> not be getting high because of my usually apathetic predispotition
> when attempting to dose? (btw, the tolerance theory couldnt be because
> I have been taking them incredibly s****adically, and spaced apart).
> Would a happy predisposition make it work? Hrmm.... btw, i dont
> currrrrrrrr if this threads archived.
 




 1 Posts in Topic:
Re: No tolerance... painkillers don't get me high?!
"Dilaudid" <  2008-01-14 21:46:15 

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tan12V112 Mon Dec 1 16:47:39 CST 2008.