I have taken 0.0075mg of Naloxone:HCl today in order to get back to a
sensible dose of dilaudid in the method posted by one of you earlier his
month. it is having very little if any effect on me. I don't know if i
have
to inc or dec the dose since i am many yrs tolerant. [2.5mg fent makes me
drowsy!]
I was hoping Mobious could shed some light on this but he hasn't posted
for
a few days...i hope he is OK?
Since this has such im****tant ramifications for all opiate users [reducing
overall quantities of drug reduces cost, makes abstenance ultimatlely
easier
if that is the goal, reduces the threat of OD, eases the side effects
etc...
so i am persuing his with vigour.....i am still a little perplexed in the
apparanet apathy from the rest of you though...this is the holey grail!
In my efforts thu far i have found that DXM is an NMDA antangonist with
the
ability to similarly reduce tolerance [different mechanism than naloxone]
and now an orphna drug called proglumide has apparently the desired
effects
thru NMDA as well.
here is the text of an interview with the author.
I( would really apreciate any experiences or literature you all may have
collected over the yrs....i am new to this group and this may be dead
topicly...
bored....but excited at the prospect.
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THE ENTHEOGEN REVIEW, PMB 808, 564 MISSION STREET, SAN FRANCISCO, CA 4105
69 VOLUME VIII, NUMBER 2 SUMMER SOLSTICE 1999
?not only does it make the opiates more effective, but it also can reverse
opiate tolerance or prevent it from being developed in the first place.
Will: Everything went to hell while you were gone, yeah? surprise.
Jonathan: Right. The iguanas ate the morning glories. Well, I don?t have
any
iguanas where I live. Nothing eats the morning glories.
Jon: Hey JONATHAN, you had mentioned in Pharmacophilia that some kind of a
stomach medication?proglumide?could be used with opiates. Have you tried
that?
Jonathan: Oh yeah. The dosage is about a quarter of a gram. Proglumide
used
to be used as an ulcer medication, but now they have more profitable ones.
Jon: I?ve also heard that you can use Tagamet? to do the same thing. Do
you
know if that?s true?
Jonathan: Is that a CCK inhibitor?
Jon: I don?t know.
Jonathan: I don?t think so. No, I think that inhibits the secretion of
hydrochloric acid in your stomach. No that wouldn?t work. CCK is a gut
hormone?cholecystokinin?that is really involved apparently in ulcers. And
so
they had CCK inhibitors at one time that were ulcer medications.
Proglumide
is one of those. But CCK in the brain is the endogenous opiate antagonist.
It?s like naltrexone and naloxone. It?s what dampens the endorphin
circuits?the endopioid circuits. And so it was found that inhibiting this
CCK is like enhancing the effects of opiates. And not only does it make
the
opiates more effective, but it also can reverse opiate tolerance or
prevent
it from being developed in the first place. Will: Really!? To the point
dosage does not have to go up at all?
Jonathan: Exactly.
Jon: Do you need to lower your dosage?
Jonathan: You can, yes.
Jon: But would it be dangerous not to?
Jonathan:Well, you?d get an enhanced effect, definitely. I wouldn?t think
it
would be dangerous. But if you have tolerance, you can actually work your
dose down by using this.
Will: Is it sold as a powder? When you say a quarter gram?
Jonathan: Well, I just bought 50 grams of it from SIGMA. It?s not on the
Usan pharmaceutical market anymore, because they have more profitable
things. It?s cheap, it?s non-toxic, it?s been approved in many countries.
There?s a good trackrecord for its use in human beings. It?s not some
experimental thing.
Jon: You can get it in other countries though, right?
Jonathan: Well, it?s not available in Spain or M?xico. Every country I go
to
I check to see if they have it. I don?t know how to find that out. But I
know the trade names for it?in the Merck Index you can look that up. And
SIGMA sells it?it?s very cheap, 50 grams is about $90.00. And so that
would
be something? I hadn?t really thought about this but that just reminds me,
that?s something that we should make for PHARMACOPHILIA. Make dose-forms
of
that.
Jon: Yeah.
Will: Absolutely. Does it in any way effect the quality of the analgesic
effect?
Jonathan: I took it first by itself, and didn?t really notice any effect.
I
didn?t know what the dose was at first, and so I started working up. Then
I
got this book called Orphan Drugs that just happened to have it in there,
but they don?t say what countries still sell it. But they list it as an
orphan drug. Jon: Does it say who manufactures it though? I mean, couldn?t
you write to the manufacturer and find out where?
Jonathan: Yeah. It?s possible. I can find out. And I will. But it may be
that the patents have expired also, and that?s another reason why it?s not
being marketed. And the dose is kind of high. And now they?re going for
more
specific things like inhibiting hydrochloric acid secretion or whatever,
and
maybe CCK inhibition isn?t a valuable treatment anymore for ulcer. But
there
are other CCK inhibitors that are known. But this is the cheapest, most
readily available one.
THE ENTHEOGEN REVIEW, PMB 808, 564 MISSION STREET, SAN FRANCISCO, CA 94105
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