On Feb 24, 6:16 pm, Joel <j...@[EMAIL PROTECTED]
> wrote:
> "Lizard" <lizardpri...@[EMAIL PROTECTED]
> wrote:
> >There is not now, and has NEVER been, a single study that linked the
> >consumption of DXM, Chlorpheniramine Maleate (the other ingredient in
> >Coricidin cough and cold) or the combination thereof to Olney's
> >lesions or ANY other brain disease. There are a few (about 6)
> >anecdotal re****ts of the Olney's lesions problem, but none have panned
> >out, and three of them later were demonstrated to be suffering not
> >from Olney's but from another degenerative disease of the brain
> >unrelated to drug consumption.
>
> >The Olney's lesions theory was ignited by White's otherwise excellent
> >but somewhat alarmist DXM faq, and he has now repudiated that section.
>
> Proof is one thing, but it's pretty clear that heavy third- and
> fourth-plateau users (people taking such doses more than once or twice
> a week) can develop NMDA-antagonist neurotoxicity. However, it may or
> may not be the largest concern - addiction itself would probably be
> the bigger issue to worry about.
>
> --
> Joel Crump
It is not clear at all. There isn't even any convincing anecdotal
evidence of it. It simply does not happen, and has NEVER happened to
anybody, as far as can be determined by any scientific method, and
there have been 3 clinical studies (one in the US, one in the
Netherlands and one in France. I am looking for the abstracts and
will post them as soon as I find them) that looked for such evidence
and found none.
Now, if what you are talking about is S*****onin Syndrome (a different
thing altogether) you are on firmer ground. While rare, and almost
always as a side effect of mixing SSRI's with very high doses of DXM,
it has been recorded. S*****onin Syndrome is tem****ary (if it doesn't
kill you, that is) and does not cause degenerative damage.
Lizard
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